(19)

(11)

EP 0 804 226 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95903602.0 (22) Date of filing: 23.11.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 48/ 00( . ) A61P 25/ 02( . ) C07K 16/ 40( . ) C12N 5/ 10( . ) C12N 15/ 00( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) C12R 1/ 19( . ) A61K 38/ 45( . ) A61P 25/ 00( . ) A61P 25/ 28( . ) C12N 1/ 21( . ) C12N 9/ 10( . ) C12N 15/ 02( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1994/013570 (87) International publication number: WO 1996/015806 (30.05.1996 Gazette 1996/25)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: HUDSON, Peter L. Germantown, MD 20874 (US) HE, Wei Wu Columbia, MD 21045 (US) ROSEN, Craig A. Laytonsville, MD 20882 (US) GOCAYNE, Jeannine D. Silver Spring, MD 20902 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)