(19)

(11)

EP 0 804 453 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95910094.0 (22) Date of filing: 17.01.1995

(51) International Patent Classification (IPC):  C07K 14/ 82( . ) G01N 33/ 574( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1995/000608 (87) International publication number: WO 1995/019369 (20.07.1995 Gazette 1995/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.01.1995 US 19950373799 (71) Applicant: VANDERBILT UNIVERSITY Nashville, TN 37240 (US)

(72) Inventors: HOLT, Jeffrey, T. Franklin, TN 37064 (US) JENSEN, Roy, A. Franklin, TN 37064 (US) PAGE, David, L. Nashville, TN 37215 (US) OBERMILLER, Patrice, S. Nashville, TN 37220 (US) ROBINSON-BENION, Cheryl, L. Nashville, TN 37218 (US) THOMPSON, Marilyn, E. Nashville, TN 37217 (US) (74) Representative: Wakerley, Helen Rachael  Reddie & Grose, 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)