(19)

(11)

EP 0 804 546 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95911712.0 (22) Date of filing: 20.01.1995

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C12N 1/ 21( . ) C12N 9/ 02( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) A61K 39/ 00( . ) C12R 1/ 91( . ) C07K 16/ 40( . ) C12N 5/ 10( . ) C12N 15/ 00( . ) C12Q 1/ 68( . ) A61K 38/ 00( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1995/001827 (87) International publication number: WO 1996/022360 (25.07.1996 Gazette 1996/34)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: HE, Wei, Wu Columbia, MD 21045 (US) MEISSNER, Paul, S. Barnesville, MD 20838 (US) HUDSON, Peter, L. Germantown, MD 20874 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)