(19)

(11)

EP 0 804 553 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 94923373.0 (22) Date of filing: 07.07.1994

(51) International Patent Classification (IPC):  C07K 14/ 80( . ) C12N 9/ 04( . ) C12N 5/ 076( . ) (86) International application number: PCT/US1994/007654 (87) International publication number: WO 1995/002041 (19.01.1995 Gazette 1995/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.07.1993 US 19930089271 (71) Applicant: LA JOLLA CANCER RESEARCH FOUNDATION La Jolla, CA 92037 (US)	(72) Inventors: MILLAN, Jose L. San Diego, CA 92131 (US) HOFMANN, Marie-Claude Encinitas, CA 92024 (US) (74) Representative: Cornish, Kristina Victoria Joy  Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)