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EP 0 804 571 A1

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(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95915957.0 (22) Date of filing: 24.04.1995

(51) International Patent Classification (IPC):  A01H 5/ 00( . ) A01N 63/ 02( . ) C12N 1/ 21( . ) C12N 7/ 00( . ) C12N 15/ 12( . ) C12R 1/ 92( . ) A01K 67/ 027( . ) C07K 14/ 435( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/GB1995/000917 (87) International publication number: WO 1995/029235 (02.11.1995 Gazette 1995/47)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.04.1994 GB 19940008466 (71) Applicant: BRITISH TECHNOLOGY GROUP LIMITED London SE1 6BU (GB)

(72) Inventors: BELL, David, Robert Nottingham NG7 2RD (GB) USHERWOOD, Peter, Norman, Russell Nottingham NG7 2RD (GB) DULUBOVA, Irina New York, NY 10021-6399 (US) VOLKOVA, Tatiana Moscow, 117871 (RU) GRISHIN, Eugene Moscow (RU) KRASNOPEROV, Valery Nelson Institute Tuxedo, NY 10987 (RU) GALKINA, Tatiana G. Shemyakin & Ovchinnikov Moscow 117871 (RU) KHOVOTCHEV, Mikhail V. Shemyakin & Ovchinnikov Moscow 117871 (RU) PLUZHNIKOV, Kirill A. Shemyakin & Ovchinnikov Moscow 117871 (RU) SHAMOTIENKO, Oleg G. London CW7 2AY olfson Labora (GB) (74) Representative: Dolan, Anthony Patrick, et al  British Technology Group 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)