(19)

(11)

EP 0 804 596 A1

(12)

(43) Date of publication: 05.11.1997 Bulletin 1997/45 (21) Application number: 95937728.0 (22) Date of filing: 17.11.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 35/ 00( . ) C07K 14/ 21( . ) C07K 14/ 475( . ) C12N 15/ 00( . ) C12P 21/ 02( . ) C12R 1/ 38( . ) A61K 38/ 00( . ) A61P 43/ 00( . ) C07K 14/ 47( . ) C07K 19/ 00( . ) C12N 15/ 62( . ) C12R 1/ 19( . ) C12R 1/ 91( . ) (86) International application number: PCT/AU1995/000767 (87) International publication number: WO 1996/016176 (30.05.1996 Gazette 1996/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.11.1994 AU 1994PM09598 (71) Applicant: CRC FOR BIOPHARMACEUTICAL RESEARCH PTY. LTD. Darlinghurst, NSW 2010 (AU)	(72) Inventors: DALY, Roger, John Randwick, NSW 2031 (AU) FIDDES, Rodney, John Randwick, NSW 2031 (AU) (74) Representative: Chapman, Paul William  Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)