(19)

(11)

EP 0 805 687 A1

(12)

(43) Date of publication: 12.11.1997 Bulletin 1997/46 (21) Application number: 96905219.0 (22) Date of filing: 24.01.1996

(51) International Patent Classification (IPC):  G01N 33/ 574( . ) A61K 31/ 52( . ) A61K 38/ 17( . ) A61K 49/ 00( . ) A61P 3/ 08( . ) A61P 35/ 00( . ) A61P 43/ 00( . ) C07K 14/ 47( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) A61K 31/ 435( . ) A61K 38/ 00( . ) A61K 47/ 48( . ) A61K 51/ 00( . ) A61P 25/ 00( . ) A61P 37/ 00( . ) C07K 14/ 415( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1996/000996 (87) International publication number: WO 1996/022787 (01.08.1996 Gazette 1996/35)

(84) Designated Contracting States: AT CH DE FR GB IT LI NL SE (30) Priority: 24.01.1995 US 19950377309 24.01.1995 US 19950377311 24.01.1995 US 19950377316 24.01.1995 US 19950377317 21.07.1995 US 19950505012 (71) Applicant: MURGITA, Robert, A. Montreal, Quebec H3H 1A7 (CA)	(72) Inventor: MURGITA, Robert, A. Montreal, Quebec H3H 1A7 (CA) (74) Representative: Killin, Stephen James, et al  Venner, Shipley & Co., 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)