(19)

(11)

EP 0 805 974 A1

(12)

(43) Date of publication: 12.11.1997 Bulletin 1997/46 (21) Application number: 96905389.0 (22) Date of filing: 23.01.1996

(51) International Patent Classification (IPC):  G01N 21/ 64( . ) G01N 27/ 447( . ) (86) International application number: PCT/US1996/001613 (87) International publication number: WO 1996/023213 (01.08.1996 Gazette 1996/35)

(84) Designated Contracting States: DE FR GB (30) Priority: 23.01.1995 US 19950376853 (71) Applicants: Murray, Anthony J. Piscataway, NJ 08855 (US) Stegemann, Josef 69118 Heidelberg (DE) Ansorge, Wilhelm 69251 Gaiberg (DE)	(72) Inventors: Murray, Anthony J. Piscataway, NJ 08855 (US) Stegemann, Josef 69118 Heidelberg (DE) Ansorge, Wilhelm 69251 Gaiberg (DE) (74) Representative: Widén, Björn, et al  Pharmacia & Upjohn AB, Patent Department 751 82 Uppsala 751 82 Uppsala (SE)