(19)

(11)

EP 0 806 965 A1

(12)

(43) Date of publication: 19.11.1997 Bulletin 1997/47 (21) Application number: 95910105.0 (22) Date of filing: 18.01.1995

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 45/ 00( . ) A61P 9/ 08( . ) C07H 21/ 04( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 9/ 10( . ) C07K 14/ 705( . ) C12P 21/ 02( . ) G01N 33/ 566( . ) (86) International application number: PCT/US1995/000740 (87) International publication number: WO 1995/019183 (20.07.1995 Gazette 1995/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.01.1994 US 19940183156 (71) Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02139 (US)	(72) Inventors: HE, Qi 4 Westgate Drive Woburn, MA 01801 (US) HABER, Edgar Salisbury, NH 03268 (US) (74) Representative: Dzieglewska, Hanna Eva, et al  Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)