(19)

(11)

EP 0 807 171 A1

(12)

(43) Date of publication: 19.11.1997 Bulletin 1997/47 (21) Application number: 95943748.0 (22) Date of filing: 12.12.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) C12N 15/ 113( . ) (86) International application number: PCT/US1995/016086 (87) International publication number: WO 1996/019572 (27.06.1996 Gazette 1996/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.12.1994 US 19940362631 (71) Applicant: HYBRIDON, Inc. Cambridge, MA 02139 (US)	(72) Inventors: TANG, Jinyan Shrewsbury, MA 01545 (US) ROSKEY, Allysen, M. Rutland, MA 01543 (US) AGRAWAL, Sudhir Shrewsbury, MA 01545 (US) (74) Representative: Vossius, Volker, Dr., et al  Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5 81679 München 81679 München (DE)