(19)
(11) EP 0 807 683 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.11.2005 Bulletin 2005/47

(45) Mention of the grant of the patent:
21.09.2005 Bulletin 2005/38

(21) Application number: 97108263.1

(22) Date of filing: 27.04.1990
(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, A61K 38/17, C07K 16/28, C12N 1/21, C12N 5/18
// (C12N1/21, C12R1:19, 1:38, 1:07, 1:465)

(54)

Endothelial cell-leukocyte adhesion molecules (ELAMs) and molecules involved in leukocyte adhesion (MILAs)

Leukozytenadhäsions-/Endothelialzell-Moleküle (ELAMs) und Moleküle wirksam bei Leukozytenadhäsion (MILAs)

Molécules d'adhésion leucocytes-cellules endothéliales (ELAMs) et molécules impliquées dans l'adhésion des leucocytes (MILAs)

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB IT LI LU NL SE

(30) Priority: 28.04.1989 US 345151
01.06.1989 US 359516
18.12.1989 US 452675

(43) Date of publication of application:
19.11.1997 Bulletin 1997/47

(60) Divisional application:
05017737.7

(62) Application number of the earlier application in accordance with Art. 76 EPC:
90911366.4 / 0458911

(73) Proprietor: Biogen Idec MA Inc.
Cambridge, Massachusetts 02142 (US)

(72) Inventors:
  • Hession, Catherine
    Hingham, MA 02043 (US)
  • Lobb, Roy R.
    Westwood MA 02090 (US)
  • Goelz, Susan E.
    Winchester MA 01890 (US)
  • Osborn, Laurelee
    Arlington, MA 02174 (US)
  • Benjamin, Christopher D.
    Beverly MA 01915 (US)
  • Rosa, Margaret D.
    Winchester MA 01890 (US)

(74) Representative: Bannerman, David Gardner et al
Withers & Rogers LLP Goldings House, 2 Hays Lane
London SE1 2HW
London SE1 2HW (GB)


(56) References cited: : 
WO-A-90/05786
   
  • BEVILACQUA M P ET AL: "ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1: AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS" SCIENCE, vol. 243, no. 4895, 3 March 1989, pages 1160-1164, XP002056080
  • BEVILACQUA MP ET AL: "Identification of an inducible endothelial-leukocyte adhesion molecule." PROC NATL ACAD SCI U S A, DEC 1987, 84 (24) P9238-42, XP002083488 UNITED STATES
  • BEVILACQUA M P ET AL: "Endothelial-leukocyte adhesion molecule-1 Elam-1 and granule membrane protein 140 GMP-140 define a new family of inducible lectin-like receptors" FASEB (FED AM SOC EXP BIOL), vol. 3, no. 3, 1989, page A610 XP002083489
  • OSBORN L ET AL: "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes." CELL, DEC 22 1989, 59 (6) P1203-11, XP002083490 UNITED STATES
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).