(19)

(11)

EP 0 808 361 A1

(12)

(43) Date of publication: 26.11.1997 Bulletin 1997/48 (21) Application number: 95939952.0 (22) Date of filing: 13.11.1995

(51) International Patent Classification (IPC):  C12N 7/ 00( . ) C07K 14/ 11( . ) C12N 7/ 02( . ) A61K 39/ 145( . ) C12N 7/ 01( . ) (86) International application number: PCT/US1995/014814 (87) International publication number: WO 1996/015232 (23.05.1996 Gazette 1996/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.11.1994 US 19940340254 (71) Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL Memphis, TN 38105-2794 (US)	(72) Inventors: WEBSTER, Robert, G. P.O. Box 318, Memphis, TN 38105 (US) KAVERIN, Nicolai V. ul.Gamaleya 16, Moscow, 123098 (RU) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)