(19)
(11) EP 0 809 511 A1

(12)

(43) Date of publication:
03.12.1997 Bulletin 1997/49

(21) Application number: 96904008.0

(22) Date of filing: 07.02.1996
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
A61P 3/ 08( . )
A61P 9/ 00( . )
A61P 27/ 02( . )
A61P 31/ 04( . )
A61P 35/ 00( . )
A61K 38/ 20( . )
A61P 3/ 10( . )
A61P 17/ 00( . )
A61P 29/ 00( . )
A61P 31/ 12( . )
(86) International application number:
PCT/EP1996/000507
(87) International publication number:
WO 1996/025171 (22.08.1996 Gazette 1996/38)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

(30) Priority: 16.02.1995 US 19950389382

(71) Applicants:
  • F. HOFFMANN-LA ROCHE AG
    4070 Basel (CH)
  • The Children's Medical Center Corporation
    Boston, Massachusetts 02115 (US)

(72) Inventors:
  • FOLKMAN, Moses, Judah
    Brookline, MA 02146 (US)
  • TRUITT, Gary, Arthur
    Bloomfield, NJ 07003 (US)
  • VOEST, Emile, Eugene
    NL-3769 BP Soesterberg (NL)

(74) Representative: Witte, Hubert, Dr., et al 
124 Grenzacherstrasse
4070 Basel
4070 Basel (CH)

   


(54) INHIBITION OF ANGIOGENESIS USING INTERLEUKIN-12