(19)

(11)

EP 0 809 697 A2

(12)

(43) Date of publication: 03.12.1997 Bulletin 1997/49 (21) Application number: 96904557.0 (22) Date of filing: 29.01.1996

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) A61K 38/ 00( . ) C12N 15/ 12( . ) A61K 48/ 00( . ) (86) International application number: PCT/US1996/001469 (87) International publication number: WO 1996/023884 (08.08.1996 Gazette 1996/36)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 30.01.1995 US 19950380051 07.06.1995 US 19950484487 23.10.1995 US 19950005809 (71) Applicant: LIGAND PHARMACEUTICALS, INC. San Diego, CA 92121 (US)	(72) Inventor: MUKHERJEE, Ranjan San Diego, CA 92127 (US) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)