(19)

(11)

EP 0 809 804 A1

(12)

(43) Date of publication: 03.12.1997 Bulletin 1997/49 (21) Application number: 95911618.0 (22) Date of filing: 13.02.1995

(51) International Patent Classification (IPC):  G01N 33/ 532( . ) G01N 21/ 76( . ) G01N 33/ 58( . ) C12Q 1/ 68( . ) G01N 33/ 533( . ) (86) International application number: PCT/US1995/001506 (87) International publication number: WO 1996/025667 (22.08.1996 Gazette 1996/38)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT SI (71) Applicant: TROPIX, INC. Bedford, MA 01730-2314 (US)	(72) Inventors: BRONSTEIN, Irena Newton, MA 02158 (US) EDWARDS, Brooks Cambridge, MA 02138 (US) VOYTA, John Sudmary, MA 01776 (US) (74) Representative: Weisert, Annekäte, Dipl.-Ing. Dr.-Ing., et al  Patentanwälte Kraus Weisert & Partner Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)