(19)

(11)

EP 0 809 806 A1

(12)

(43) Date of publication: 03.12.1997 Bulletin 1997/49 (21) Application number: 96903435.0 (22) Date of filing: 03.01.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) C07K 16/ 28( . ) C12N 15/ 02( . ) G01N 33/ 577( . ) (86) International application number: PCT/US1996/000370 (87) International publication number: WO 1996/024848 (15.08.1996 Gazette 1996/37)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.02.1995 US 19950384039 (71) Applicant: CASE WESTERN RESERVE UNIVERSITY Cleveland, OH 44106-7015 (US)	(72) Inventors: BRUDER, Scott, P. Mareland Hills, OH 44022 (US) CAPLAN, Arnold, I. Cleveland Heights, OH 44121 (US) HAYNESWORTH, Stephen, E. Cleveland Heights, OH 44118 (US) (74) Representative: Segeth, Wolfgang  Patentanwälte Louis, Pöhlau, Lohrentz & Segeth Postfach 30 55 90014 Nürnberg 90014 Nürnberg (DE)