(19)

(11)

EP 0 810 862 A2

(12)

(43) Date of publication: 10.12.1997 Bulletin 1997/50 (21) Application number: 96903205.0 (22) Date of filing: 21.02.1996

(51) International Patent Classification (IPC):  A61K 31/ 4406( . ) A61K 31/ 4436( . ) A61K 31/ 47( . ) A61K 31/ 443( . ) A61K 31/ 444( . ) (86) International application number: PCT/JP1996/000394 (87) International publication number: WO 1996/025933 (29.08.1996 Gazette 1996/39)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.02.1995 JP 19950033960 (71) Applicant: Takeda Chemical Industries, Ltd. Osaka-shi, Osaka 541 (JP)	(72) Inventors: TERASHITA, Zen-ichi Suita-shi, Osaka 565 (JP) KATO, Kaneyoshi Kawanishi-shi, Hyogo 666-01 (JP) SOHMA, Takenobu Tokyo 171 (JP) (74) Representative: Dowden, Marina  Elkington and Fife Prospect House, 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)