(19)

(11)

EP 0 810 873 A1

(12)

(43) Date of publication: 10.12.1997 Bulletin 1997/50 (21) Application number: 96904846.0 (22) Date of filing: 22.02.1996

(51) International Patent Classification (IPC):  A61K 31/ 425( . ) A61K 38/ 06( . ) A61P 37/ 04( . ) A61K 31/ 505( . ) A61P 31/ 12( . ) (86) International application number: PCT/EP1996/000736 (87) International publication number: WO 1996/026734 (06.09.1996 Gazette 1996/40)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 25.02.1995 GB 19950003850 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)	(72) Inventor: McDADE, Hugh Brownlie, Glaxo R. & D. Limited Middlesex UB60HE 6 (GB) (74) Representative: Quillin, Helen Kaye, et al  Glaxo Wellcome plc Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)