(19)

(11)

EP 0 812 204 A1

(12)

(43) Date of publication: 17.12.1997 Bulletin 1997/51 (21) Application number: 96907881.0 (22) Date of filing: 28.02.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 48/ 00( . ) C07K 19/ 00( . ) A61K 38/ 43( . ) A61P 35/ 00( . ) C12N 15/ 62( . ) (86) International application number: PCT/US1996/002271 (87) International publication number: WO 1996/026733 (06.09.1996 Gazette 1996/40)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.03.1995 US 19950397435 (71) Applicant: Varshavsky, Alexander La Canada Flintridge, CA 91011-1326 (US)	(72) Inventor: Varshavsky, Alexander La Canada Flintridge, CA 91011-1326 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)