(19)

(11)

EP 0 812 354 A2

(12)

(43) Date of publication: 17.12.1997 Bulletin 1997/51 (21) Application number: 96903616.0 (22) Date of filing: 19.01.1996

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) C12N 15/ 12( . ) (86) International application number: PCT/US1996/000847 (87) International publication number: WO 1996/023070 (01.08.1996 Gazette 1996/35)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 23.01.1995 US 19950377423 (71) Applicant: LIGAND PHARMACEUTICALS, INC. San Diego, CA 92121 (US)	(72) Inventor: LAMPH, William, W. San Diego, CA 92109 (US) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)