(19)

(11)

EP 0 812 360 A1

(12)

(43) Date of publication: 17.12.1997 Bulletin 1997/51 (21) Application number: 95910081.0 (22) Date of filing: 11.01.1995

(51) International Patent Classification (IPC):  G01N 33/ 15( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 35/ 00( . ) C07K 16/ 40( . ) C12N 15/ 09( . ) A61K 35/ 76( . ) A61K 39/ 395( . ) A61P 31/ 12( . ) A61P 43/ 00( . ) C12N 9/ 10( . ) C12N 15/ 54( . ) (86) International application number: PCT/US1995/000421 (87) International publication number: WO 1996/021736 (18.07.1996 Gazette 1996/33)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20878 (US)	(72) Inventors: GREENE, John M. Gaithersburg, MD 20878 (US) ROSEN, Craig A. Laytonsville, MD 20882 (US) KIRKNESS, Ewen F. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)