(19)

(11)

EP 0 812 361 A1

(12)

(43) Date of publication: 17.12.1997 Bulletin 1997/51 (21) Application number: 96908533.0 (22) Date of filing: 27.02.1996

(51) International Patent Classification (IPC):  A23L 1/ 305( . ) C07K 14/ 47( . ) C12N 15/ 09( . ) C12N 15/ 64( . ) C12P 21/ 00( . ) C12R 1/ 07( . ) C12R 1/ 225( . ) A61K 38/ 17( . ) C12N 9/ 12( . ) C12N 15/ 62( . ) C12N 15/ 70( . ) A61K 38/ 00( . ) C12R 1/ 19( . ) C12R 1/ 46( . ) (86) International application number: PCT/US1996/002623 (87) International publication number: WO 1996/027017 (06.09.1996 Gazette 1996/40)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 27.02.1995 US 19950394999 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: MUKERJI, Pradip Gahanna, OH 43230 (US) THURMOND, M., Jennifer Gahanna, OH 43230 (US) HANSSON, L., Stig S-907 38 Umea (SE) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)