(19)

(11)

EP 0 814 854 A1

(12)

(43) Date of publication: 07.01.1998 Bulletin 1998/02 (21) Application number: 96902672.0 (22) Date of filing: 16.01.1996

(51) International Patent Classification (IPC):  A61M 1/ 16( . ) A61M 1/ 36( . ) G01M 3/ 18( . ) A61M 5/ 145( . ) A61M 1/ 30( . ) B01F 5/ 06( . ) A61M 1/ 00( . ) (86) International application number: PCT/US1996/000458 (87) International publication number: WO 1996/022117 (25.07.1996 Gazette 1996/34)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.01.1995 US 19950373703 (71) Applicant: JOHNSON & JOHNSON CORPORATION New Brunswick, NJ 08933-0001 (US)	(72) Inventors: BRIGGS, Dennis, A. West Chester, PA 19382 (US) LEE, Kyu, H. Bryn Mawr, PA 19010 (US) GARRO, Joseph, Jr. King of Prussia, PA 19406 (US) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)