(19)

(11)

EP 0 814 855 A1

(12)

(43) Date of publication: 07.01.1998 Bulletin 1998/02 (21) Application number: 96909619.0 (22) Date of filing: 11.03.1996

(51) International Patent Classification (IPC):  A61K 35/ 18( . ) C12M 3/ 00( . ) A61M 1/ 16( . ) A61M 1/ 36( . ) F25B 21/ 02( . ) (86) International application number: PCT/US1996/003211 (87) International publication number: WO 1996/028199 (19.09.1996 Gazette 1996/42)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.03.1995 US 19950402145 06.10.1995 US 19950004906P (71) Applicant: EntreMed, Inc. Rockville, Maryland 20850 (US)	(72) Inventors: MESEROL, Peter, M. Montville, NJ 07045 (US) PRODELL, Rita, C. West Orange, NJ 07052 (US) ACKER, Jesse, L. Rockaway, NJ 07866 (US) (74) Representative: Patentanwälte Sternagel & Fleischer  Braunsberger Feld 29 51429 Bergisch Gladbach 51429 Bergisch Gladbach (DE)