(19)

(11)

EP 0 815 103 A1

(12)

(43) Date of publication: 07.01.1998 Bulletin 1998/02 (21) Application number: 96904963.0 (22) Date of filing: 08.03.1996

(51) International Patent Classification (IPC):  C07D 295/ 12( . ) A61K 31/ 4427( . ) A61K 31/ 445( . ) A61K 31/ 47( . ) A61K 31/ 495( . ) A61K 31/ 55( . ) A61P 35/ 00( . ) C07D 211/ 20( . ) C07D 211/ 26( . ) C07D 211/ 62( . ) C07D 217/ 04( . ) C07D 295/ 185( . ) C07D 401/ 14( . ) C07D 409/ 14( . ) C07D 417/ 12( . ) C07D 513/ 04( . ) C07F 9/ 6509( . ) A61K 31/ 40( . ) A61K 31/ 4433( . ) A61K 31/ 4465( . ) A61K 31/ 472( . ) A61K 31/ 505( . ) A61P 7/ 02( . ) C07D 207/ 08( . ) C07D 211/ 22( . ) C07D 211/ 34( . ) C07D 215/ 36( . ) C07D 217/ 16( . ) C07D 401/ 12( . ) C07D 409/ 12( . ) C07D 413/ 14( . ) C07D 417/ 14( . ) C07F 9/ 59( . ) C07F 9/ 6558( . ) (86) International application number: PCT/GB1996/000520 (87) International publication number: WO 1996/029327 (26.09.1996 Gazette 1996/43)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.03.1995 GB 19950005538 (71) Applicant: Novartis AG 4058 Basel (CH)

(72) Inventors: HOYLE, William Bramhall Stockport Cheshire SK7 2PY (GB) HOWARTH, Graham, Arton Ollerton Cheshire WA16 8RF (GB) BRUNDISH, Derek, Edward Horsham West Sussex RH13 6DU (GB) KANE, Peter, Daniel Horsham West Sussex RH13 6SD (GB) WALKER, Clive, Victor Horsham West Sussex RH12 4HW (GB) HAYLER, Judy East Grinstead Sussex RH19 3XW (GB) FULLERTON, Joseph, David Worthing West Sussex BN14 9DQ (GB) SMITH, Garric, Paul Guildford Surrey GU1 4DY (GB) WATHEY, William, Bernard Horsham West Sussex RH12 4HL (GB) LE GRAND, Darren, Mark Horsham West Sussex RH12 5HJ (GB) ALLEN, Mark, Christopher Horsham West Sussex RH12 1LS (GB) HEROLD, Peter CH-4144 Arlesheim (CH) (74) Representative: Roth, Bernhard M., et al  Novartis AG Geistiges Eigentum Konzern 4002 Basel 4002 Basel (CH)