(19)

(11)

EP 0 815 222 A1

(12)

(43) Date of publication: 07.01.1998 Bulletin 1998/02 (21) Application number: 96903098.0 (22) Date of filing: 16.02.1996

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) C12N 15/ 12( . ) A61K 48/ 00( . ) C07K 16/ 18( . ) A61K 38/ 00( . ) (86) International application number: PCT/GB1996/000366 (87) International publication number: WO 1996/025495 (22.08.1996 Gazette 1996/38)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 16.02.1995 GB 19950003075 04.08.1995 GB 19950015979 17.10.1995 GB 19950021366 12.01.1996 GB 19960000622 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: SWANN, Karl, Andrew London WC1E 4AL (GB) LAI, Francis, Anthony, National Inst. of Med. Res. London NW7 1AA (GB) (74) Representative: Hallybone, Huw George, et al  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)