(19)

(11)

EP 0 815 229 A2

(12)

(43) Date of publication: 07.01.1998 Bulletin 1998/02 (21) Application number: 96911399.0 (22) Date of filing: 21.03.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 14/ 47( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C07K 14/ 705( . ) C12N 15/ 00( . ) C12N 15/ 12( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1996/004037 (87) International publication number: WO 1996/029409 (26.09.1996 Gazette 1996/43)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.03.1995 US 19950408015 20.09.1995 US 19950530569 (71) Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH New York, New York 10105 (US) LEIDEN UNIVERSITY 2300 RA Leiden (NL)

(72) Inventors: GAUGLER, Beatrice, Inst.Ludwig p.l.Rech.s.l.Cancer B-1200 Brussels (BE) VAN DEN EYNDE, Benoit, Inst.Ludwig plRech.slCancer B-1200 Brussels (BE) SCHRIER, Peter NL-2312 AV Leiden (NL) BROUWENSTIJN, Nathalie NL-2312 AV Leiden (NL) BOON-FALLEUR, Thierry, Inst.Ludwig pl Rech.Cancer B-1200 Brussels (BE) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)