(19)

(11)

EP 0 818 957 A2

(12)

(43) Date of publication: 21.01.1998 Bulletin 1998/04 (21) Application number: 96911563.0 (22) Date of filing: 04.04.1996

(51) International Patent Classification (IPC):  A23L 2/ 52( . ) A23L 1/ 302( . ) A23L 1/ 304( . ) A61K 31/ 59( . ) A61K 33/ 06( . ) A23L 1/ 30( . ) A23L 1/ 303( . ) A61K 31/ 375( . ) A61K 31/ 715( . ) (86) International application number: PCT/US1996/004601 (87) International publication number: WO 1996/031130 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.04.1995 US 19950418393 07.04.1995 US 19950418391 07.04.1995 US 19950418729 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)

(72) Inventors: MAZER, Terrence, Bruce Reynoldsburg, OH 43068 (US) DEWILLE, Normanella, Torres Columbus, OH 43220 (US) CHANDLER, Michael, Allen Gahanna, OH 43230 (US) RAGAN, Robert, John Gahanna, OH 43230 (US) SNOWDEN, Gregory, Allan Westerville, OH 43082 (US) GERAGHTY, Maureen, Elizabeth Columbus, OH 43235 (US) JOHNSON, Catherine, Dubinin Dublin, OH 43017 (US) DRAYER, Lonnie, Richard Gahanna, OH 43230 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)