(19)

(11)

EP 0 818 998 A1

(12)

(43) Date of publication: 21.01.1998 Bulletin 1998/04 (21) Application number: 96909846.0 (22) Date of filing: 25.03.1996

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 47/ 14( . ) A61K 31/ 352( . ) (86) International application number: PCT/US1996/003962 (87) International publication number: WO 1996/031203 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 03.04.1995 US 19950415721 (71) Applicant: ASCENT PHARMACEUTICALS, INC. Billerica, MA 01821 (US)	(72) Inventors: CLEMENTE, Emmett Manchester, MA 01944 (US) MENDES, Robert, W. Dedham, MA 02026 (US) ANAEBONAM, Aloysius, O. Burlington, MA 01803 (US) AHMED, Mumtaz Westford, MA 01886 (US) (74) Representative: Fisher, Adrian John  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)