(19)

(11)

EP 0 819 127 A1

(12)

(43) Date of publication: 21.01.1998 Bulletin 1998/04 (21) Application number: 96909164.0 (22) Date of filing: 02.04.1996

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) C07D 471/ 04( . ) A61P 29/ 00( . ) (86) International application number: PCT/EP1996/001438 (87) International publication number: WO 1996/031509 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 04.04.1995 GB 19950006965 14.06.1995 GB 19950012099 05.08.1995 GB 19950016117 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)

(72) Inventors: BESWICK, Paul, J., Glaxo Research and Dev. Ltd. Stevenage, Herts. SG1 2NY (GB) CAMPBELL, Ian, B., Glaxo Research and Dev. Ltd. Stevenage, Herts. SG1 2NY (GB) NAYLOR, Alan, Glaxo Research and Development Ltd. Stevenage, Herts. SG1 2NY (GB) (74) Representative: Lane, Graham Mark Hamilton, et al  Glaxo Wellcome plc Glaxo Wellcome House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)