(19)

(11)

EP 0 819 171 A1

(12)

(43) Date of publication: 21.01.1998 Bulletin 1998/04 (21) Application number: 96908869.0 (22) Date of filing: 21.03.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 00( . ) C07K 14/ 74( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) A61P 37/ 04( . ) C07K 16/ 28( . ) C12N 15/ 02( . ) C12N 15/ 12( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1996/003765 (87) International publication number: WO 1996/031604 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.04.1995 US 19950419648 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: FISHER, Susan, J. San Francisco, CA 94122 (US) LIBRACH, Clifford Toronto, Ontario M6C 2G7 (CA) DAMSKY, Caroline Belmont, CA 94002 (US) McMASTER, Michael, T. Oakland, CA 94619 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)