(19)

(11)

EP 0 820 309 A2

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 95944392.0 (22) Date of filing: 22.12.1995

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61K 35/ 14( . ) A61K 39/ 395( . ) A61P 7/ 06( . ) A61P 35/ 02( . ) C07K 16/ 00( . ) C12N 15/ 02( . ) A01N 1/ 00( . ) A61K 35/ 28( . ) A61K 48/ 00( . ) A61P 33/ 02( . ) A61P 37/ 00( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1995/016850 (87) International publication number: WO 1996/019965 (04.07.1996 Gazette 1996/30)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.12.1994 IL 19940112109 (71) Applicant: YEDA RESEARCH AND DEVELOPMENT CO., Ltd. Rehovot 76 110 (IL)	(72) Inventor: REISNER, Yair 68037 Old Jaffa (IL) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)