(19)

(11)

EP 0 820 442 A1

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 96909088.0 (22) Date of filing: 01.04.1996

(51) International Patent Classification (IPC):  C07D 245/ 02( . ) A61K 31/ 396( . ) A61K 31/ 445( . ) A61K 31/ 451( . ) A61K 31/ 472( . ) A61K 31/ 535( . ) A61P 3/ 08( . ) A61P 25/ 04( . ) A61P 29/ 00( . ) C07D 203/ 10( . ) C07D 211/ 22( . ) C07D 211/ 52( . ) C07D 211/ 62( . ) C07D 217/ 26( . ) C07D 265/ 30( . ) C07D 295/ 15( . ) A61K 31/ 395( . ) A61K 31/ 40( . ) A61K 31/ 4465( . ) A61K 31/ 47( . ) A61K 31/ 495( . ) A61K 31/ 5375( . ) A61P 25/ 00( . ) A61P 25/ 06( . ) A61P 43/ 00( . ) C07D 207/ 16( . ) C07D 211/ 46( . ) C07D 211/ 60( . ) C07D 217/ 22( . ) C07D 243/ 08( . ) C07D 295/ 08( . ) C07D 295/ 205( . ) (86) International application number: PCT/DK1996/000151 (87) International publication number: WO 1996/031474 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.04.1995 DK 19950000417 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: ANDERSEN, Knud, Erik DK-2765 Smoerum (DK) OLSEN, Uffe Bang DK-2625 Vallensbaek (DK) ANDERSEN, Henrik, Sune DK-2100 Koebenhavn (DK) HOHLWEG, Rolf DK-3490 Kvistgaard (DK) JOERGENSEN, Tine, Krogh DK-2730 Herlev (DK) MADSEN, Peter DK-2880 Bagsvaerd (DK) ZDENEK, Polivka 150 00 Praha 5 (CZ) ALEXANDRA, Silhánková 142 00 Praha 4 (CZ) KAREL, Sindelár 140 00 Praha 4 (CZ)