(19)

(11)

EP 0 820 453 A1

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 96911520.0 (22) Date of filing: 01.04.1996

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) A61P 43/ 00( . ) C07K 5/ 06( . ) C07K 5/ 078( . ) A61P 7/ 02( . ) C07K 5/ 02( . ) C07K 5/ 065( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/004460 (87) International publication number: WO 1996/031504 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 04.04.1995 US 19950416244 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: FENG, Dong-Mei Rathway, NJ 07065 (US) BOCK, Mark, G. Rahway, NJ 07065 (US) FREIDINGER, Roger, M. Rahway, NJ 07065 (US) VACCA, Joseph, P. Rahway, NJ 07065 (US) DORSEY, Bruce, D. Rahway, NJ 07065 (US) (74) Representative: Cole, William Gwyn  European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)