(19)

(11)

EP 0 820 514 A2

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 96912726.0 (22) Date of filing: 12.04.1996

(51) International Patent Classification (IPC):  C12N 9/ 00( . ) C12N 15/ 82( . ) (86) International application number: PCT/US1996/005095 (87) International publication number: WO 1996/032484 (17.10.1996 Gazette 1996/46)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 14.04.1995 US 19950422560 06.06.1995 US 19950468793 05.03.1996 US 19960611107 (71) Applicant: ARCH DEVELOPMENT CORPORATION Chicago, IL 60637 (US)	(72) Inventors: HASELKORN, Robert Chicago, IL 60637 (US) GORNICKI, Piotr Chicago, IL 60615 (US) (74) Representative: Glawe, Delfs, Moll & Partner  Patentanwälte Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)