(19)

(11)

EP 0 820 525 A1

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 96915311.0 (22) Date of filing: 05.04.1996

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) G02B 21/ 34( . ) (86) International application number: PCT/US1996/004720 (87) International publication number: WO 1996/031626 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.04.1995 US 19950418704 (71) Applicant: University of New Mexico Albuquerque, NM 87131 (US)	(72) Inventors: KIM, In, C. Albuquerque, NM 87110 (US) THOMPSON, Donald, M. Albuquerque, NM 87108 (US) SARTO, Gloria, E. Albuquerque, NM 87109 (US) (74) Representative: Van Breda, Jacobus  Octrooibureau Los & Stigter, P.O. Box 20052 1000 HB Amsterdam 1000 HB Amsterdam (NL)