(19)

(11)

EP 0 820 591 A1

(12)

(43) Date of publication: 28.01.1998 Bulletin 1998/05 (21) Application number: 96908266.0 (22) Date of filing: 01.04.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) B01J 20/ 285( . ) G01N 33/ 538( . ) B01J 20/ 281( . ) G01N 30/ 88( . ) G01N 33/ 68( . ) (86) International application number: PCT/GB1996/000790 (87) International publication number: WO 1996/032642 (17.10.1996 Gazette 1996/46)

(84) Designated Contracting States: CH DE FR IT LI (30) Priority: 08.04.1995 GB 19950007366 (71) Applicant: ZENECA LIMITED London W1Y 6LN (GB)	(72) Inventors: HALES, Neil, James Macclesfield Cheshire SK10 4TG (GB) CLAYTON, Edward Macclesfield Cheshire SK10 4TG (GB) (74) Representative: Phillips, Neil Godfrey Alasdair  Intellectual Property Department ZENECA Pharmaceuticals Mereside Alderley Park Macclesfield Cheshire SK10 4TG Macclesfield Cheshire SK10 4TG (GB)