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(11)

EP 0 821 694 A1

(12)

(43) Date of publication: 04.02.1998 Bulletin 1998/06 (21) Application number: 96912813.0 (22) Date of filing: 17.04.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) C07K 14/ 435( . ) (86) International application number: PCT/US1996/005262 (87) International publication number: WO 1996/033206 (24.10.1996 Gazette 1996/47)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.04.1995 US 19950423561 15.02.1996 US 19960599556 29.03.1996 US 19960624123 (71) Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION Salt Lake City, Utah 84108 (US)

(72) Inventors: SHON, Ki-Joon, University of Utah, Biology Dept. Salt Lake City, UT 84112 (US) GRILLEY, Michelle, M., University of Utah Salt Lake City, UT 84112 (US) OLIVERA, Baldomero, M. Salt Lake City, UT 84108 (US) YOSHIKAMI, Doju Salt Lake City, UT 84111 (US) MARSH, Maren Salt Lake City, UT 84105 (US) CRUZ, Lourdes, J. Salt Lake City, UT 84114 (US) HILLYARD, David, R. Salt Lake City, UT 84124 (US) (74) Representative: Rambelli, Paolo, et al  c/o JACOBACCI & PERANI S.p.A. Corso Regio Parco, 27 10152 Torino 10152 Torino (IT)