(19)
(11) EP 0 821 740 A1

(12)

(43) Date of publication:
04.02.1998 Bulletin 1998/06

(21) Application number: 96912909.0

(22) Date of filing: 19.04.1996
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61K 35/ 12( . )
A61K 38/ 00( . )
A61K 38/ 21( . )
A61K 38/ 37( . )
A61K 48/ 00( . )
A61P 37/ 00( . )
C07K 14/ 55( . )
C07K 14/ 755( . )
C12N 15/ 867( . )
 A61K 31/ 00( . )
A61K 35/ 76( . )
A61K 38/ 20( . )
A61K 38/ 22( . )
A61K 38/ 43( . )
A61P 9/ 00( . )
A61P 37/ 02( . )
C07K 14/ 555( . )
C12N 5/ 10( . )
(86) International application number:
PCT/US1996/005432
(87) International publication number:
WO 1996/033281 (24.10.1996 Gazette 1996/47)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 20.04.1995 US 19950425176
20.04.1995 US 19950425762

(71) Applicants:
  • CHIRON CORPORATION
    Emeryville CA 94025 (US)
  • SYSTEMIX, INC.
    Palo Alto, California 94304 (US)

(72) Inventors:
  • JOLLY, Douglas, J.
    Leucadia, CA 92024 (US)
  • ROBBINS, Joan, M.
    San Diego, CA 92109 (US)
  • KERR, William, G.
    Palo Alto, CA 94306 (US)

(74) Representative: Irvine, Jonquil Claire 
J.A. KEMP & CO. 14 South Square Gray's Inn
London WC1R 5LX
London WC1R 5LX (GB)

   


(54) HIGH EFFICIENCY EX VIVO TRANSDUCTION OF HEMATOPOIETIC STEM CELLS BY RECOMBINANT RETROVIRAL PREPARATIONS