(19)

(11)

EP 0 822 821 A1

(12)

(43) Date of publication: 11.02.1998 Bulletin 1998/07 (21) Application number: 95916431.0 (22) Date of filing: 17.04.1995

(51) International Patent Classification (IPC):  A61K 31/ 05( . ) A61K 47/ 48( . ) (86) International application number: PCT/US1995/004707 (87) International publication number: WO 1996/032950 (24.10.1996 Gazette 1996/47)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE (71) Applicants: Sanchez, Robert A. Carlsbad, CA 92009 (US) HENDLER, Sheldon Saul La Jolla, CA 92037 (US)	(72) Inventors: Sanchez, Robert A. Carlsbad, CA 92009 (US) HENDLER, Sheldon Saul La Jolla, CA 92037 (US) (74) Representative: Maschio, Antonio, et al  D Young & Co, 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)