(19)

(11)

EP 0 822 940 A2

(12)

(43) Date of publication: 11.02.1998 Bulletin 1998/07 (21) Application number: 96912916.0 (22) Date of filing: 18.04.1996

(51) International Patent Classification (IPC):  G01N 33/ 15( . ) C07K 14/ 775( . ) G01N 33/ 569( . ) C07K 14/ 47( . ) C12N 5/ 073( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1996/005441 (87) International publication number: WO 1996/033214 (24.10.1996 Gazette 1996/47)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.04.1995 US 19950423409 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: FISHER, Susan, J. San Francisco, CA 94122 (US) GENBACEV, Olga Mountain View, CA 94040 (US) FOULK, Russell Pacifica, CA 94044 (US) CLAUSER, Karl, R. San Bruno, CA 94066 (US) BURLINGAME, Alama, L. Sausalito, CA 94965 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)