(19)
(11) EP 0 822 983 A1

(12)

(43) Date of publication:
11.02.1998 Bulletin 1998/07

(21) Application number: 96913801.0

(22) Date of filing: 17.04.1996
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61K 45/ 00( . )
A61P 9/ 00( . )
A61P 25/ 28( . )
A61P 35/ 00( . )
A61P 43/ 00( . )
C07K 5/ 113( . )
C12N 9/ 64( . )
A61K 31/ 70( . )
A61K 48/ 00( . )
A61P 25/ 00( . )
A61P 31/ 00( . )
A61P 37/ 00( . )
C07B 61/ 00( . )
C07K 16/ 40( . )
C12Q 1/ 68( . )
(86) International application number:
PCT/US1996/005282
(87) International publication number:
WO 1996/033268 (24.10.1996 Gazette 1996/47)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 21.04.1995 US 19950426557

(71) Applicants:
  • MERCK & CO., INC.
    Rahway, New Jersey 07065 (US)
  • MERCK FROSST CANADA INC.
    Kirkland Quebec H9H 3L1 (CA)

(72) Inventors:
  • MILLER, Douglas, K.
    Rahway, NJ 07065 (US)
  • THORNBERRY, Nancy, A.
    Rahway, NJ 07065 (US)
  • NICHOLSON, Donald, W.
    Kirkland, Quebec H9H 3L1 (CA)
  • ALI, Ambereen
    Kirkland, Quebec H9H 3L1 (CA)
  • VAILLANCOURT, John, P.
    Kirkland, Quebec H9H 3L1 (CA)

(74) Representative: Thompson, John Dr. 
Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) APOPAIN