(19)
(11) EP 0 824 523 A1

(12)

(43) Date of publication:
25.02.1998 Bulletin 1998/09

(21) Application number: 96915767.0

(22) Date of filing: 09.05.1996
(51) International Patent Classification (IPC): 
A61K 31/ 00( . )
A61K 31/ 445( . )
A61P 9/ 00( . )
A61P 31/ 00( . )
A61P 37/ 06( . )
C07D 207/ 24( . )
C07D 211/ 74( . )
C07D 243/ 08( . )
C07D 267/ 10( . )
C07D 413/ 06( . )
C07D 471/ 10( . )
 A61K 31/ 40( . )
A61K 31/ 55( . )
A61P 9/ 02( . )
A61P 37/ 00( . )
C07D 207/ 22( . )
C07D 211/ 72( . )
C07D 223/ 12( . )
C07D 267/ 08( . )
C07D 403/ 06( . )
C07D 413/ 12( . )
(86) International application number:
PCT/US1996/006831
(87) International publication number:
WO 1996/035677 (14.11.1996 Gazette 1996/50)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 10.05.1995 US 19950438321

(71) Applicant: G.D. Searle & Co.
Chicago Illinois 60680 (US)

(72) Inventors:
  • HANSEN, Donald, W., Jr.
    Skokie, IL 60077 (US)
  • HAGEN, Timothy, J.
    Gurnee, IL 60031 (US)
  • KRAMER, Steven, W.
    Des Plaines, IL 60016 (US)
  • METZ, Suzanne
    Chesterfield, MO 63017 (US)
  • PETERSON, Karen, B.
    Vernon Hills, IL 60061 (US)
  • SPANGLER, Dale, P.
    Deerfield, IL 60015 (US)
  • TOTH, Mihaly, V.
    St. Louis, MO 63122 (US)
  • FOK, Kam, F.
    St. Louis, MO 63146 (US)
  • WEBBER, R., Keith
    St. Peters, MO 63376 (US)
  • TJOENG, Foe, S.
    Manchester, MO 63021 (US)
  • PITZELE, Barnett, S.
    Skokie, IL 60076 (US)
  • HALLINAN, E., Ann
    Evanston, IL 60202 (US)

(74) Representative: Weisert, Annekäte, Dipl.-Ing. Dr.-Ing. 
Patentanwälte Kraus Weisert & Partner Thomas-Wimmer-Ring 15
80539 München
80539 München (DE)

   


(54) NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES