(19)

(11)

EP 0 824 542 A1

(12)

(43) Date of publication: 25.02.1998 Bulletin 1998/09 (21) Application number: 96920107.0 (22) Date of filing: 18.04.1996

(51) International Patent Classification (IPC):  C12N 15/ 10( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1996/005480 (87) International publication number: WO 1996/033207 (24.10.1996 Gazette 1996/47)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 18.04.1995 US 19950425684 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)	(72) Inventors: STEMMER, Willem, P., C. Los Gatos, CA 95030 (US) LIPSHUTZ, Robert, J. Palo Alto, CA 94301 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)