(19)

(11)

EP 0 824 586 A1

(12)

(43) Date of publication: 25.02.1998 Bulletin 1998/09 (21) Application number: 95920385.0 (22) Date of filing: 11.05.1995

(51) International Patent Classification (IPC):  C12N 9/ 90( . ) C12Q 1/ 68( . ) C12N 15/ 61( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1995/005785 (87) International publication number: WO 1996/035778 (14.11.1996 Gazette 1996/50)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: JI, Hongjun San Diego, CA 92129 (US) ROSEN, Craig A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)