(19)
(11) EP 0 825 870 A1

(12)

(43) Date of publication:
04.03.1998 Bulletin 1998/10

(21) Application number: 96920109.0

(22) Date of filing: 19.04.1996
(51) International Patent Classification (IPC): 
A61K 39/ 00( . )
A61K 38/ 00( . )
C07K 14/ 47( . )
(86) International application number:
PCT/US1996/005783
(87) International publication number:
WO 1996/032957 (24.10.1996 Gazette 1996/47)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 20.04.1995 US 19950426784
19.10.1995 US 19950545456
20.10.1995 US 19950546571

(71) Applicant: BRIGHAM & WOMEN'S HOSPITAL
Boston, Massachusetts 02115 (US)

(72) Inventors:
  • HAFLER, David, A.
    West Newton, MA 02156 (US)
  • WEINER, Howard, L.
    Brookline, MA 02146 (US)
  • KUCHROO, Vijay, K.
    Newton, MA 02159 (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät 
Maximilianstrasse 58
80538 München
80538 München (DE)

   


(54) MODULATION OF CYTOKINE PATTERNS OF HUMAN AUTOREACTIVE T-CELL CLONES