(19)

(11)

EP 0 826 037 A1

(12)

(43) Date of publication: 04.03.1998 Bulletin 1998/10 (21) Application number: 96920297.0 (22) Date of filing: 17.05.1996

(51) International Patent Classification (IPC):  C12N 9/ 24( . ) (86) International application number: PCT/US1996/007217 (87) International publication number: WO 1996/036701 (21.11.1996 Gazette 1996/51)

(84) Designated Contracting States: AT BE DE DK FI FR GB IE NL SE (30) Priority: 19.05.1995 US 19950445090 (71) Applicant: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. Athens, Georgia 30602 (US)	(72) Inventors: LI, Xin-Liang Athens, GA 30605 (US) LJUNGDAHL, Lars, G. Athens, GA 30605 (US) CHEN, Huizhong Athens, GA 30605 (US) (74) Representative: Fisher, Adrian John  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)