ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS - Patent 0828737

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EP 0 828 737 A1

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(43)	Date of publication:
	18.03.1998 Bulletin 1998/12

(21)	Application number: 96920476.0

(22)	Date of filing: 24.05.1996

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International Patent Classification (IPC):

A61K 31/ 42^{( . )}
A61K 31/ 505^{( . )}
A61P 9/ 14^{( . )}
C07D 413/ 06^{( . )}
C07D 413/ 14^{( . )}
C07D 417/ 12^{( . )}

A61K 31/ 44^{( . )}
A61P 7/ 02^{( . )}
A61P 43/ 00^{( . )}
C07D 413/ 12^{( . )}
C07D 417/ 06^{( . )}
C07D 471/ 04^{( . )}

(86)	International application number:
	PCT/US1996/007646

(87)	International publication number:
	WO 1996/037492 (28.11.1996 Gazette 1996/52)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

25.05.1995 US 19950450646
31.05.1995 US 19950455768
09.05.1996 US 19960647132

(71)	Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY
	Wilmington, Delaware 19898 (US)

(72)	Inventors:
	VOSS, Matthew, Ernst Lincoln University, PA 19352-9112 (US) JADHAV, Prabhakar, Kondaji Wilmington, DE 19808-4314 (US) SMALLHEER, Joanne, Marie Landenberg, PA 19350-9368 (US) BATT, Douglas, Guy Wilmington, DE 19803-2615 (US) PITTS, William, John Newark, DE 19711-8309 (US) WITYAK, John West Grove, PA 19390-9439 (US)

(74)	Representative: Pett, Christopher Phineas, et al
	Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)

(54)	ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS