(19)

(11)

EP 0 828 751 A1

(12)

(43) Date of publication: 18.03.1998 Bulletin 1998/12 (21) Application number: 95918991.0 (22) Date of filing: 05.05.1995

(51) International Patent Classification (IPC):  C07K 14/ 72( . ) A61K 38/ 00( . ) C07K 16/ 28( . ) (86) International application number: PCT/US1995/005616 (87) International publication number: WO 1996/034877 (07.11.1996 Gazette 1996/49)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: SOPPET, Daniel, R. Centreville, VA 22020 (US) LI, Yi Sunnyvale, California 94086 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)