(19)
(11) EP 0 828 843 A1

(12)

(43) Date of publication:
18.03.1998 Bulletin 1998/12

(21) Application number: 96915791.0

(22) Date of filing: 14.05.1996
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61P 43/ 00( . )
C07K 14/ 52( . )
C12N 5/ 10( . )
A61K 38/ 00( . )
A61K 38/ 22( . )
C07K 14/ 475( . )
C07K 19/ 00( . )
C12P 21/ 02( . )
(86) International application number:
PCT/US1996/006861
(87) International publication number:
WO 1996/036720 (21.11.1996 Gazette 1996/51)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 16.05.1995 US 19950441863

(71) Applicant: BRISTOL-MYERS SQUIBB COMPANY
Princeton, NJ 08543-4000 (US)

(72) Inventors:
  • CULOUSCOU, Jean-Michel
    F-78110 Le Vésinet (FR)
  • CARLTON, Gary, W.
    Seattle, WA 98119 (US)
  • ARUFFO, Alejandro, A.
    Edmonds, WA 98020 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) RECOMBINANT HEREGULINS AND THEIR BIOLOGICAL FUNCTIONS UPON RECEPTOR ACTIVATION